

Miscalculations or Misinterpretations?
Be an Informed Consumer in the Age of NumbersGigerenzer provides the simple mental tools that allow anyone to make sense of the statistics that bombard us daily in the media. It is exactly his point that one does not need to be a rocket scientist (or professional statistician) to understand the numbers used by professionals, from personal physicians to DNA experts, that affect our lives and livelihoods.
If I could recommend only one book to address "numerical illiteracy," this would be it. You will learn some essential skills in a clearly informative and entertaining way.
EVERYone should read this!Gigerenzer bares the truth that doctors conceal because of ignorance or greed. Every woman should read his chapter on the risks and benefits of mammograms. The rate of false positives for mammograms is a whopping ninety percent. The cost is not measured by x-ray charges alone (although a radiologist huffed out of a meeting with a gynecologist who stopped recommending mammograms -- they make big bucks from those tests!). Think of the unnecessary biopsies -- and the unnecessary surgery because biopsies have error rates too.
Cancer tests do not cure or prevent cancer. They may reduce the risk of death, although a comparison between screened and unscreened populations shows that very few lives are actually saved this way. And there is no risk reduction unless early detection affords access to a cure.
AIDS tests also carry risks. The rate of false positives among a healthy, "safe-sex" population is about fifty percent. The author describes horror stories of disease-free people who were mis-diagnosed. They lost jobs, homes and friends; some sued for recovery but at least one committed suicide.
Our health care system spends millions on tests because both patients and doctors are ill-informed. We demand a cure and the medical system finds a way to give us the illusion of progress.
It's not just the US. The author found ignorance of false positives for AIDS tests in Germany. When I lived in Canada, the provincial health system bombarded us with propaganda for mammograms.
Gigerenzer has done the world a great service by writing this book and presenting data in a reader-friendly fashion. I suspect there is a human tendency to look for certainty and today's medical tests seems to be the equivalent of divining rods and astrology of three hundred years ago. Now I wish he'd take a look at academic and career tests, most of which also give a form of "false positives." We'd like a yes or no in this world, but alas, mostly we have to learn to live with the maybes.


Simply Excellent!
Excellent overview of probabilistic computational biologyProbabilistic modeling has been applied to many different areas, including speech recognition, network performance analysis, and computational radiology. An overview of probabilistic modeling is given in the first chapter, and the authors effectively introduce the concepts without heavy abstract formalism, which for completeness they delegate to the last chapter of the book. Bayesian parameter estimation is introduced as well as maximum likelihood estimation. The authors take a pragmatic attitude in the utility of these different approaches, with both being developed in the book.
This is followed by a treatment of pairwise alignment in Chapter Two, which begins with substitution matrices. They point out, via some exercises, the role of physics in influencing particular alignments (hydrophobicity for example). Global alignment via the Gotoh algorithm and local alignment via the Smith-Waterman algorithm, are both discussed very effectively. Finite state machines with accompanying diagrams are used to discuss dynamic programming approaches to sequence alignment. The BLAST and FASTA packages are briefly discussed, along with the PAM and BLOSUM matrices.
Hidden Markov models are treated thoroughly in the next chapter with the Viterbi and Baum-Welch algorithms playing the central role. HIdden Markov models are then used in Chapter 4 for pairwise alignment. State diagrams are again used very effectively to illustrate the relevant ideas. Profile hidden Markov models which, according to the authors are the most popular application of hidden Markov models, are treated in detail in the next chapter. A very surprising application of Voronoi diagrams from computational geometry to weighting training sequences is given.
Several different approaches, such as Barton-Sternberg, CLUSTALW, Feng-Doolittle, MSA, simulated annealing, and Gibbs sampling are applied to multiple sequence alignment methods in Chapter 6. It is very well written, with the only disappointment being that only one exercise is given in the entire chapter. Phylogenetic trees are covered in Chapter 7, with emphasis placed on tree building algorithms using parsimony. The next chapter discusses the same topic from a probabilistic perspective. This to me was the most interesting part of the book as it connects the sequence alignment algorithms with evolutionary models.
The authors switch gears starting with the next chapter on transformational grammars. It is intriguing to see how concepts used in compiler construction can be generalized to the probabilistic case and then applied to computational biology. The PROSITE database is given as an example of the application of regular grammars to sequence matching. This chapter is fascinating reading, and there are some straightforward exercises illustrating the main points.
The last chapter covers RNA structure analysis, which introduces the concept of a pseudoknot. These are not to be confused with the usual knot constructions that can be applied to the topology of DNA, but instead result from the existence of non-nested base pairs in RNA sequences. The authors discuss many other techniques used in RNA sequence analysis and take care to point out which ones are more practical from a computational point of view. Surprisingly, genetic algorithms and algorithms based on Monte Carlo sampling are not discussed in the book, but the authors do give references for the interested reader.
The best attribute of this book is that the authors take a pragmatic point of view of how mathematics can be applied to problems in computational biology. They are not dogmatic about any particular approach, but instead fit the algorithm to the problem at hand.
Surprisingly deep and clear book, even viewed from outside.


Great book
An excellent book!
A GREAT referenceI use it as a reference- to refresh myself on a technique, or to consult when I run into a problem- this book has yet to let me down and has been able to answer any question or solve any problem that I've had.
You see this book cited in academic behavioral research, but the book does a great job of explaining things in a managerial way as well.
Other of these reviews have criticized it for going on too long on an example or a technique- for that I PRAISE this book- I WANT that extra information. I'm reminded of that quote from "Amadeus"- "Too many notes." I WANT as many notes as I can get- that's what makes it so much more helpful.
If you are looking for a great reference book for multivariate techniques, look no further.


additional comments on second editionRecently I did some consulting for a colleague. He had some data that he wanted to test for the presence of a single outlier. I referred him to the procedures due to Grubbs and Dixon. I also mention the book by Barnett and Lewis which has the most detailed account of outlier methods. However, Barnett and Lewis is so detailed that it can be overwhelming for a beginner. Fortunately my friend has a copy of Sokal and Rohlf's book. I believe he has the same second edition that I have. They provide a good elementary treatment of these methods and have tables to use. Unfortunately, I discovered that the tables are in a separate supplement. My colleague has the supplement but I don't. The reader should be aware that the supplement is needed to implement some of the procedures in the book that require tables. It is not expensive but it is essential. I imagine that the same is true for the third edition but I am not sure. Regardless this is an excellent refer for biostatisticians and practitioners including regulatory affairs analysts and medical writers.
nice reference for users of biostatisticsImportant topics that are not included are survival analysis, sample size determination and Bayesian methods.
Excellent self-tutorial

Best Beginners Book EVER! Pierce is Great.This book is practical, it get's straight to the point and tells you what information theory can actually (and is actually) used for. Alot of information theory books don't
have any practical value whatsoever (Reza, Ash, Khinchin) as they seem to be written more by mathemeticians than scientists/engineers... Pierce has written several books in the golden era, and he is one of the very best authors. His insight, knowledge and clarity of writing are almost unparalleled by no other author. Only Claude Shannon, Bernard Sklar and James Massey rival John Pierce in exceptionally simple writing style.
The book has very few mathematical equations. The ones he presents are so simple it's basic middle school mathematics. In lieiu of math equations, Pierce explains information theory in plain english. If you know nothing whatsoever about information theory... this is the book I would highly recommend first.... ...
An Absolute GemThis is the ONLY book of which I am aware which attempts to present Shannon's results to the educated lay reader, and Pierce does a crackerjack job of it. Notwithstanding, this is not a book for the casual reader. The ideas underlying the theory are inherently subtle and mathematical, although there are numerous practical manifestations of them in nature, and in human "information transmission" behavior. On the other hand, this is a work which repays all effort invested in its mastery many times over.
Worth a Careful ReadingHowever, the clarity of the presentation tends to obscure just how profound and deep the thinking involved really is. During the first reading, Pierce's insights made the material seem almost obvious. Later I would get doubts that such straightforward approaches could be correct, and then would think about the correctness of his assertions. This is why this is a great book, because it focuses on important stuff, and doesn't shy away from deep topics. This is a great book for those interested in the basis of information theory, on a side note Shannon's original papers are also quite readable.


Good How to Do BooksGiven the increasingly user-friendly statistical software on the market, this book offers a quick antidote for the rising number of button pushers, by showing budding statisticians the implications of using a technique ignorantly. This is done without making the technique inscrutable to the reader.
While the new edition offers some additional information - the cost conscious buyer could easily find considerable value in older editions.
It's a classic, the first big buy for MV stats
A clear step by step intro. to multivariate stats

Great book for practical applications
An Introduction to More Effective ExperimentationWhat Dr. Roy has achieved in his book on experimental design is to clearly explain why this is so and to provide the tools which allows his readers to overcome their ingrained beliefs and adopt a more effective method of designing their own experimental programs.
Of particular interest is his discussion of experimental design using orthogonal arrays (Chapter 4) for it is in this part of the book that the full power of modern approaches to experimentation become most evident. Here, he illustrates how a set of as few as eight experiments can be used to determine how three presumable independent factors, such as time, temperature and concentration, can be studied to obtain detailed information not only on how each factor individually effects the quality of the final product, but also on the extent to which the factors interact.
Historically, learning this type of technique for designing experiments has been a daunting task since somewhat tedious mathematically manipulations are required for both the design of the experiment and the analyses of the resulting data. However, included with Dr. Roy's book is complete software which eliminates the need for the experimenter to either manually solve the handful of equations needed to extract the results in useful form, or to develop custom spreadsheets in an attempt to automate the process. The software is easy to use and includes all of the tables and data which are used in the book to illustrate the principles of experimental design. The software is also capable of assisting the experimenter in designing sets of up to eight concurrent experiments, rapidly analyzing the data and generating graphical and tabular presentations which greatly aid in the interpretation of the results.
This is an extremely useful book which can have a major beneficial effect on the productivity of any laboratory engaged in experimental process research such as crystal growth, chemical synthesis or manufacturing. By allowing the reader to overcome his innate aversion to varying more than one experimental factor at a time, the book makes it possible for the reader to become a much more productive scientist or engineer and become a role model for his coworkers to emulate.
Must have for Quality Control Professionals and Educators1. The discussion group (usenet) hosted by Dr Roy is fantastic. If by chance you don't "get it" from reading the book, a simple question posted to the usenet frequently gets you an answer, often within a few hours (its a vocal crowd!!). Many times, the author himself responds to usenet questions. And, on at least one instance, after I repeatdly asked my question, he began exchanging emails with me, which then led to some pleasant phone disscussions.
2. User friendly software and support. See above.
3. Taguichi is frequently attacked by full blown Design of Experiments statistical types who miss the whole point. I strongly encourage all professionals interested in gauging quality control to try out his books and the free software downloads....
An excellent book with powerful software and support......
Reads like a winner, looks like a winner, performs likes a winner....... need I say more...
Auburn Alabama


Bayesian survival analysis
Bayesian survival analysis
A Great Book

Barrons is the way to go.
Never taken a statistics class and got a 5
It got me a five;and I didn't even take the class.

Excellent in illustrating mathematics through fictionMy main example is that throughout the book, Holmes and Watson make reference to the year 1900 (their present year) as being the beginning of a new century. I feel certain that Holmes at least would know that centuries do not begin until the year one, in this case 1901. When Watson mentioned it, I felt sure that Bruce was taking the normal tack of making him obviously less intelligent than his partner (the man *is* a doctor, for crying out loud, give him *some* credit), but when Holmes mentions it later, I was duly perturbed.
Bruce also uses characters purely to tack on surprise endings to his stories, one of which did not work for this reviewer. In one story, the pair meet the Reverend Charles Dodgson, which any bibliophile knows is the real name of Lewis Carroll, but does not present this information until the last paragraph of the story. The surprise ending, using the pseudonym, was therefore lost on me.
In another story, there is no solution presented to a murder. This irked me no end at first, but then I realized that there being no solution to the mystery better illustrated the mathematical principle being explained. I still prefer my murders to have solutions, however.
All in all, this is an entertaining book. Bruce's skills as a storyteller and his ability to mix lessons into his stories is commendable. The stories, as Holmes pastiches, ring true overall, only clunking during the details I have mentioned, such as certain actions that seem totally out of character. One other example is when Sherlock and Mycroft are explaining a principle and Sherlock pulls out a graph to illustrate. Bruce (as Watson) writes the following (to the best of my memory): 'I jumped up, knocking over my chair, and cried, 'I have a horror of algebra!'' I couldn't help but laugh! This behavior from one of the most beloved characters in literature?
But, as I said, as a whole the book succeeds, and if you can overlook these details and engross yourself in the superb storytelling, you will enjoy yourself, and probably be educated in the process.
Watson we've got a winner!
A Wonderful, enjoyable book!The stories were not designed to top those of doyle but to make some interesting probability and decision making concepts approachable, relevent, and enjoyable. This they did wonderfully. As someone who was turned off to math after years of dull, abstract school lecture, my interest arose from my work in business and computer science. Some of these concepts were not new to me, but all were from new angles. I found .the math easy to follow(depressingly difficult to predict!) and only wished I had not run out of pages. I plan not only to check out the author's other work, but some of the additional reading he kindly suggests in the notes. Thank you Mr. Bruce for and enjoyable read.
A couple of caveats are in order however, and they are, shall we say, doozies. Gigerenzer states that there is ample evidence that smoking causes lung cancer. But he fails to consider why people from Asian and Pacific-Island cultures have some of the highest smoking rates in the world, but some of the lowest cancer rates. Any why do longitudinal studies show that people from these same cultures have much higher rates of cancer once they migrate to modern countries? Is it diet, smoking, a combination of the two, or something else that "causes" cancer? Likewise, Gigerenzer states that there is strong evidence that secondhand smoke is harmful to health. But he fails to mention the cardinal rule of toxicology: the dose, or concentration of a substance, makes the poison, not the substance itself. It is only in modern energy efficient air-tight buildings that smoke can be sufficiently concentrated so as to become an irritant, let alone a perceived health hazard. Thus, it may not be secondhand smoke, but the environment of tight buildings that is the source of the problem.
Thus, Gigerenzer fails to point out that all statistics and numbers must be actively interpreted and are relative in meaning to the interpreter. This involves a social filtering process not discussed in the book. Also, government may legitimate some health and crime statistics, when they may be bogus. As an aficionado of Gigerenzer's books, maybe he will write a sequel on the interpretation, misinterpretation, and social and political construction of statistics.